BACKground: Estimating postmortem interval is effective forensic tool for investigating   time of death useful in criminology. Many gross, microscopic and molecular methods   available for estimating postmortem interval. Human prostate is last soft tissue organ
to degenerate in human cadavers and its histopathology in cadavers can be used for   estimation of post mortem interval. Studies reported Histopathologies of different   organs to estimate postmortem intervals for purpose of calculating time since death. In
our study we tried to observe Post mortem interval estimation in human cadavers with  Histopathological changes in Prostrate.
oBjeCtives: To estimate postmortem interval from Histopathological examination of  prostate in human cadavers and identify Histopathological changes in human prostate in  relation to time since death.  methodology: Prostate from cadavers registered for autopsy in our institute were  examined grossly along with histopathology as per criteria laid down for sampling.  results: Histopathological sections from total of 36 human cadavers were studied. Changes  like epithelial disruption of acini, nuclear changes, inflammatory cell collection in stroma, fatty  degeneration and sequential necrotic changes were reported in relation to time since death. Earliest degeneration changes in prostrate acini began at 6 hours postmortem and changes in  stroma began at 12 hours. First atrophic changes in acini began at 19 hours postmortem and   continued to progress till 3 days after which   identification of any glandular or stromal   tissue became extremely difficult.  ConClusion: Significant changes in  Prostrate were documented between 6  hours and 72 hours postmortem. Changes  in human prostate can be used for  estimating postmortem interval